ParkinsonCanadaV1, Main, Exploration, bibRecord, 000D26

Morbidities in Rapid Eye Movement Sleep Behaviour Disorders

Identifieur interne : 000D26 ( Main/Exploration ); précédent : 000D25; suivant : 000D27

Morbidities in Rapid Eye Movement Sleep Behaviour Disorders

Auteurs : Poul Jennum [Danemark] ; Geert Mayer [Allemagne] ; Ju Yo-El [États-Unis] ; Ron Postuma [Canada]

Source :

Sleep medicine [ 1389-9457 ] ; 2013.

RBID : PMC:3979349

Abstract

Idiopathic Rapid Eye Movement (REM) Sleep Behaviour Disorder (iRBD, RBD without any obvious comorbid major neurological disease), is strongly associated with numerous comorbid conditions. The most prominent is that with neurodegenerative disorders, especially synuclein-mediated disorders, above all Parkinson Disease (PD). Idiopathic RBD is an important risk factor for the development of synucleinopathies. Comorbidity studies suggest that iRBD is associated with a number of other potential pre-motor manifestations of synucleinopathies such as, cognitive and olfactory impairment, reduced autonomic function, neuropsychiatric manifestations and sleep complaints. Furthermore, patients with PD and RBD may have worse prognosis in terms of impaired cognitive function and overall morbidity/mortality; in dementia, the presence of RBD is strongly associated with clinical hallmarks and pathological findings of dementia with Lewy bodies. These findings underline the progressive disease process, suggesting involvement of more brain regions in patients with a more advanced disease stage. RBD is also associated with narcolepsy, and it is likely that RBD associated with narcolepsy is a distinct subtype associated with different comorbidities. RBD is also associated with antidepressant medications, autoimmune conditions, and, in rare cases, brainstem lesions.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979349

DOI: 10.1016/j.sleep.2012.11.002
PubMed: 23375425
PubMed Central: 3979349

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p id="P2">Idiopathic Rapid Eye Movement (REM) Sleep Behaviour Disorder (iRBD, RBD without any obvious comorbid major neurological disease), is strongly associated with numerous comorbid conditions. The most prominent is that with neurodegenerative disorders, especially synuclein-mediated disorders, above all Parkinson Disease (PD). Idiopathic RBD is an important risk factor for the development of synucleinopathies. Comorbidity studies suggest that iRBD is associated with a number of other potential pre-motor manifestations of synucleinopathies such as, cognitive and olfactory impairment, reduced autonomic function, neuropsychiatric manifestations and sleep complaints. Furthermore, patients with PD and RBD may have worse prognosis in terms of impaired cognitive function and overall morbidity/mortality; in dementia, the presence of RBD is strongly associated with clinical hallmarks and pathological findings of dementia with Lewy bodies. These findings underline the progressive disease process, suggesting involvement of more brain regions in patients with a more advanced disease stage. RBD is also associated with narcolepsy, and it is likely that RBD associated with narcolepsy is a distinct subtype associated with different comorbidities. RBD is also associated with antidepressant medications, autoimmune conditions, and, in rare cases, brainstem lesions.</p>
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La maladie de Parkinson au Canada (serveur d'exploration)

Morbidities in Rapid Eye Movement Sleep Behaviour Disorders

Morbidities in Rapid Eye Movement Sleep Behaviour Disorders

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Abstract

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	La maladie de Parkinson au Canada (serveur d'exploration)
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